TY - JOUR T1 - Alteraciones del metabolismo fosfocálcico JO - Medicine VL - 11 IS - 16 PY - 2012 T2 - AU - Hawkins, F. AU - de Mingo Domínguez, M.L. AU - Sotillo Rodríguez, F. AU - Guadalix Iglesias, S. SN - 03045412 M3 - 10.1016/S0304-5412(12)70407-9 DO - 10.1016/S0304-5412(12)70407-9 UR - https://medicineonline.eshttps://www.medicineonline.es/en-alteraciones-del-metabolismo-fosfocalcic-articulo-S0304541212704079 AB - Calcium and phosphorus homeostasis is controlled by bidirectional fluxes at intestinal, kidney and bone. Both are necessary for cellular functions, bone mineralization, and their homeostasis is controlled by systemic and local factors like PTH, vitamin D and FGF23-Klotho axis. Calcium balance depend ends of body deposits, related to intestinal absorption, renal excretion and bone remodeling. Bone balance is modifying by growth, aging and hereditary of acquired diseases. PTH and 1,25OHD actions are well known, and recently FGF23 have been implicated in phosphate regulation; it acts at renal level by union to Klotho-FGFR1 complex. The excess and deficiency of FGF23 raise disease with hypo and hyperphosphatemia. KW - PTH (patathormone) KW - 1,25 OHD (calcitriol) KW - FGF23 (fibroblas growth factor) KW - Bone remodelling KW - Mineral homeostasis ER -